Understanding the implications of ocular toxicity is essential for the safe development of therapeutics. The eye, being a sensitive organ, can react adversely to systemic drugs, making ocular toxicology a critical aspect of preclinical research. At Creative Bioarray, we specialize in ocular toxicology services, providing a comprehensive range of assessments to evaluate the safety of various substances on ocular health.

The Importance of Ocular Toxicity Assessments

Drug-induced ocular toxicity is increasingly recognized due to the proliferation of new medications. Adverse ocular reactions can manifest due to both pharmacodynamic and pharmacokinetic interactions. Consequently, a thorough assessment is necessary to determine causality and rule out other potential causes. Our ocular toxicology research is pivotal, offering insights into how drugs may affect eye health.

Our Expertise in Ocular Toxicology

Creative Bioarray is equipped to support any phase of your preclinical development program. We employ specialized techniques, including electroretinography (ERG), optical coherence tomography (OCT), tonometry, and fundus angiography, to facilitate detailed evaluations of ocular health during toxicological assessments.

Comprehensive Ocular Toxicology Services

Our ocular toxicology services include:

• Lacrimation assessment
• Pupillary diameter testing
• Ocular irritation studies
• Evaluating tolerability and sensitization
• Assessing toxicity related to contact lenses and ocular implants
• Single-dose ocular toxicity
• Multiple-dose subacute and chronic ocular toxicity

Administration Methodologies

Various routes for drug administration are utilized to ensure precise assessments tailored to the study’s needs. These include:

• Intravitreal
• Periocular
• Subretinal
• Retrobulbar
• Intrastromal
• Anterior and posterior chamber administration
• Conjunctival or subconjunctival

Collaborating with Experts

Our team comprises qualified ophthalmologists who collaborate closely with experienced pathologists. This partnership ensures a thorough interpretation of results, enhancing the reliability of our findings. All tests are meticulously documented to provide comprehensive insights into potential ocular side effects.